Gene of the Month – June: SLC47A1
Combining various multi-omics approaches and statistical models, the researchers integrated genome, epigenome, methylome and transcriptome information and single-cell sequencing data to find genetic determinants of human kidney function and to provide new insights into the relevant role of epigenetic changes. They were able to identify 878 loci, including 126 new loci, that are signficantly associated with kidney function.
The results of the study have been published in Nature Genetics.
Liu H, Doke T, Guo D, … Susztak K. Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. Nat Genet. 2022 Jun 16. doi: 10.1038/s41588-022-01097-w. Epub ahead of print.